CD5; T-cell surface glycoprotein CD5; lymphocyte antigen T1/Leu-1 (CD5, LEU1)
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Function
- may act as a receptor in regulating T-cell proliferation
- interacts with CD72/LYB-2
Structure
contains 3 SRCR domains
Compartment
membrane
Expression
- B-cells of mantle zone
- B-cells in peritoneal & pleural cavities
- almost all T-cells
Pathology
- expressed in
- B cell CLL/small lymphocytic lymphoma
- mantle cell lymphoma
- hairy cell leukemia
- most T-cell malignancies
- thymic carcinomas (spindle cell thymomas negatively stain for antibody)
More general terms
References
- ↑ Cotran et al Robbins Pathologic Basis of Disease, 5th ed. W.B. Saunders Co, Philadelphia, PA 1994 pg 637
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=921
- ↑ UniProt http://www.uniprot.org/uniprot/P06127.html