B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL)

Introduction

See chronic lymphocytic leukemia.

Microscopic pathology

• small lymphocytes
• some may show plasmacytoid differentiation

Immunophenotype

• surface IgM weak/IgM +
• IgD +
• CD5 +
• CD10 -
• CD11c weak
• CD19 +
• CD20 weak
• CD22 weak
• CD23 +/-
• CD43 +
• CD79a +
• CD79b -/weak
• cyclin D1 -
• FMC7 -/weak

Genetics

• chromosomal translocation t(11;19)(q13;p13) involving FSTL3 with CCDN1 is found in a case of B-cell chronic lymphocytic leukemia
• translocation t(14;19)(q32;q13.1) involving BCL3 with immunoglobulin gene regions is associated with B-CLL
• chromosomal translocation t(X;11)(q21;q23) involving BRWD3 with ARHGAP20, does not result in fusion transcripts but disrupts both genes
• BRWD3 is down-regulated in a majority of the B-cell CLL cases
• may be associated with defects in ATM gene
• chromosomal translocation t(8;12)(q24;q22) involving MYC with BTG1 may be a cause of B-cell chronic lymphocytic leukemia

More general terms

• peripheral B-cell lymphoid neoplasm
• chronic lymphocytic leukemia (CLL)
• small lymphocytic lymphoma

Database

• OMIM: https://mirror.omim.org/entry/109543
• OMIM: https://mirror.omim.org/entry/151400