CD11c; integrin alpha-X; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; Leu M5; CD11 antigen-like family member C (ITGAX, CD11C)
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Function
- component of integrin alpha-X/beta-2 (CD11c/CD18)
Structure
- integrin I-domain (insert) is a VWFA domain
- integrins with I-domains do not undergo protease cleavage
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
- contains 1 VWFA domain
Compartment
membrane
Expression
- activated CD4/CD8+ T cells ~50%
- granulocytes
- lymphocytes
- macrophages
- activated microglia
- NK cells
- predominantly expressed in monocytes & granulocytes
Pathology
- expressed in:
- AML-M4/M5 ~50%
- hairy cell leukemia (virtually all)
- B-CLL (associated with good prognosis)
- genetic variations in CD11c influence susceptibility to systemic lupus erythematosus[3]
More general terms
Component of
References
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3687
- ↑ 3.0 3.1 Hom G, Graham RR, Modrek B et al Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008 Feb 28;358(9):900-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18204098