microglia (Hortega cell)

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Introduction

Brain mononuclear phagocytes with functions similar to tissue macrophages:

Function

Microglia populate the brain early in fetal development & persist as long-lived cells. They mature in the brain parenchyma & display a quiescent phenotype.

Pathology

Comparative biology

More general terms

Additional terms

References

  1. Benveniste et al, Neurochemistry International 39:381, 2001
  2. 2.0 2.1 Vasek MJ, Garber C, Dorsey D et al A complement-microglial axis drives synapse loss during virus- induced memory impairment. Nature. 2016 Jun 22;534(7608):538-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27337340
  3. 3.0 3.1 Bisht K, Okojie KA, Sharma K et al Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nature Communications, 2021; Sep 6;12(1):5289 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34489419 PMCID: PMC8421455 Free PMC article