CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; fractalkine receptor; G-protein coupled receptor 13; V28; beta chemokine receptor-like 1; CMK-BRL-1; CMKBLR1 (CX3CR1, CMKBRL1, GPR13)

Function

• receptor for the CX3C chemokine fractalkine & mediates both its adhesive & migratory functions

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=3

Expression

expressed in lymphoid & neural tissues

Pathology

• coreceptor with CD4 for HIV-1 virus envelope protein (in vitro)
• isoform 2 & isoform 3 seem to be more potent HIV coreceptors than isoform 1

Polymorphism

• variations in CX3CR1 are associated with rapid progression to AIDS; increased susceptibility to HIV infection & rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype

More general terms

• chemokine receptor (chemoattractant receptor)
• G-protein coupled receptor; serpentine receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1524
• OMIM: https://mirror.omim.org/entry/601470
• OMIM: https://mirror.omim.org/entry/609423
• UniProt: http://www.uniprot.org/uniprot/P49238.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1524