HIV coreceptor

Introduction

Different strains of HIV-1 include M-tropic (replicates efficiently in macrophages, poorly in T-cell lines), TCL-tropic (adapted to grow in continuous T-cell lines but poorly if at all in macrophages) and dual-tropic. All are capable of growing in activated primary CD4+ T-cells.

CXCR4 and CCR5 were identified as coreceptors (with CD4) for TCL-tropic and M-tropic HIV-1 strains respectively

More specific terms

• C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192 (CCR2, CMKBR2)
• C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; eosinophil eotaxin receptor; CD193 (CCR3, CMKBR3)
• C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; HIV-1 fusion coreceptor; CHEMR13; sCD195 (CCR5, CMKBR5)
• C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; GPR-CY6; GPRCY6; chemokine receptor-like 1; CKR-L1; TER1; CMKBRL2; CC-chemokine receptor CHEMR1; CDw198 (CCR8, CKRL1, CMKBR8, CMKBRL2)
• C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; stromal cell-derived factor 1 receptor; SDF-1 receptor; fusin; leukocyte-derived seven transmembrane domain receptor; LESTR; LCR1; FB22; neuropeptide Y receptor Y3; NPYRL; HM89; CD184 (CXCR4)
• CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; fractalkine receptor; G-protein coupled receptor 13; V28; beta chemokine receptor-like 1; CMK-BRL-1; CMKBLR1 (CX3CR1, CMKBRL1, GPR13)