C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; stromal cell-derived factor 1 receptor; SDF-1 receptor; fusin; leukocyte-derived seven transmembrane domain receptor; LESTR; LCR1; FB22; neuropeptide Y receptor Y3; NPYRL; HM89; CD184 (CXCR4)

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Function

Structure

Compartment

cell membrane

Alternative splicing

named isoforms=2

Additional isoforms seem to exist

Expression

Pathology

Pharmacology

Notes

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P61073.html
  2. CXCR4base; CXCR4 mutation db http://bioinf.uta.fi/CXCR4base/
  3. Wikipedia; Note: CXC chemokine receptors entry http://en.wikipedia.org/wiki/CXC_chemokine_receptors
  4. Wikipedia; Note: CXCR4 entry http://en.wikipedia.org/wiki/CXCR4
  5. SeattleSNPs http://pga.gs.washington.edu/data/cxcr4/
  6. Tachibana K et al The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393:591-4, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9634237
  7. Zou YR et al Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595-9, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9634238
  8. 8.0 8.1 Herzog H Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA Cell Biol. 1993 Jul-Aug;12(6):465-71. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8329116
  9. 9.0 9.1 Jazin EE et al A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul Pept. 1993 Sep 22;47(3):247-58. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8234909
  10. 10.0 10.1 Burger JA, Stewart DJ. CXCR4 chemokine receptor antagonists: perspectives in SCLC. Expert Opin Investig Drugs. 2009 Apr;18(4):481-90. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19335276
  11. 11.0 11.1 Burger JA, Stewart DJ, Wald O, Peled A. Potential of CXCR4 antagonists for the treatment of metastatic lung cancer. Expert Rev Anticancer Ther. 2011 Apr;11(4):621-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21504328

Database