tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase, TAT)

Function

• catalyzes the 1st step in the catabolism of tyrosine, the reversible transfer of the amino group of tyrosine to 2-oxo-glutarate to form 4-hydroxyphenylpyruvate & L-glutamate
• amino-acid degradation; L-phenylalanine degradation
• acetoacetate & fumarate from L-phenylalanine: step 2/6

L-tyrosine + 2-oxoglutarate
           <-->
4-hydroxyphenylpyruvate + L-glutamate

Cofactor: pyridoxal phosphate (putative)

Structure

• homodimer (putative)
• belongs to the class-1 pyridoxal-phosphate-dependent aminotransferase family

Pathology

• defects in TAT are the cause of tyrosinemia type 2

More general terms

• aminotransferase

Additional terms

• tyrosinemia type 2 (Richner-Hanhart syndrome)

Database

• UniProt: http://www.uniprot.org/uniprot/P17735.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6898
• OMIM: https://mirror.omim.org/entry/276600