WHIM syndrome; warts, hypogammaglobulinemia, infections, & myelokathexis

Pathology

• immunodeficiency

Genetics

• associated with defects in CXCR4

Clinical manifestations

• extensive human papillomavirus (HPV) infection
  • warts

Laboratory

• complete blood count: neutropenia
• serum protein electrophoresis: hypogammaglobulinemia
• bone marrow aspirates from affected individuals contain abundant mature myeloid cells (myelokathexis)

More general terms

• genetic syndrome (multisystem disorder)

Database

• OMIM: https://mirror.omim.org/entry/193670