C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192 (CCR2, CMKBR2)
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Function
- receptor for the MCP-1, MCP-3 & MCP-4 chemokines
- transduces a signal by increasing intracellular Ca+2
Structure
- N-glycosylated
- belongs to the G-protein coupled receptor 1 family
Compartment
Alternative splicing
named isoforms=2
Pathology
- alternative coreceptor with CD4 for HIV-1 infection
- binds to HIV-1 Tat
Polymorphism
- variations in CCR2 are associated with relative resistance to HIV1
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P41597.html
- ↑ Wikipedia; CC chemokine receptors entry http://en.wikipedia.org/wiki/CC_chemokine_receptors
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/ccr2/
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1231
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7292
- OMIM: https://mirror.omim.org/entry/601267
- OMIM: https://mirror.omim.org/entry/609423
- UniProt: http://www.uniprot.org/uniprot/P41597.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1231