resistance & susceptibility to HIV1

Genetics

• coinfection with GB virus C affords some protection
• trim5-alpha of rhesus monkey inhibits HIV-1 replication (reverse transcriptase). trim5-alpha of human does NOT
• variations in CCR2 are associated with relative resistance to HIV1
  • CCR2 gene p.Val64Ile
• variations in CCR5
  • associated with susceptibility or resistance to HIV1
  • influence the rate of progression to AIDS after infection
  • loincs for CCR5 gene mutation, CCR5 gene c.794-825del
• variations in CX3CR1
  • associated with rapid progression to AIDS
  • increased susceptibility to HIV infection & rapid progression to AIDS are associated with the Ile-249/ Met-280 haplotype

Additional terms

• HIV1 infection; human immunodeficiency virus-1 infection

Database

• OMIM: https://mirror.omim.org/entry/609423