C-C motif chemokine 13; CK-beta-10; monocyte chemoattractant protein 4; monocyte chemotactic protein 4; MCP-4; NCC-1; small-inducible cytokine A13 (CCL13, MCP4, NCC1, SCYA13)

Function

• chemotactic for monocytes, lymphocytes, basophils, eosinophils,
• not chemotactic for neutrophils
• signals through CCR2B & CCR3 receptors
• role in accumulation of leukocytes at both sides of allergic & non-allergic inflammation
• may be involved in recruitment of monocytes into the arterial wall during the disease process of atherosclerosis
• may play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens
• one major form (form long), & two minor forms (short chain & medium chain) are produced by differential signal peptide cleavage
• the medium chain is about 30-fold less active than the long chain
• can bind heparin

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• widely expressed
• found in small intestine, thymus, colon, lung, trachea, stomach & lymph node
• low levels seen in pulmonary artery smooth muscle cells
• induced by IL-1 & TNF

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6357
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6357
• OMIM: https://mirror.omim.org/entry/601391
• UniProt: http://www.uniprot.org/uniprot/Q99616.html