C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; eosinophil eotaxin receptor; CD193 (CCR3, CMKBR3)

Function

• receptor for a C-C type chemokine
• binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1 delta
• subsequently transduces a signal by increasing the intracellular Ca+2

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in eosinophils
• trace amounts expressed in neutrophils & monocytes

Pathology

• alternative coreceptor with CD4 for HIV-1 infection
• binds to HIV-1 Tat

More general terms

• CC chemokine receptor
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1232
• OMIM: https://mirror.omim.org/entry/601268
• UniProt: http://www.uniprot.org/uniprot/P51677.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1232