C-C motif chemokine 15; chemokine CC-2; HCC-2; Leukotactin-1; LKN-1; MIP-1 delta; macrophage inflammatory protein 5; MIP-5; Mrp-2b; NCC-3; small-inducible cytokine A15 (CCL15, MIP5, NCC3, SCYA15)

Function

• chemotactic for monocytes & T-cells
• not chemotactic for B-cells, eosinophils, neutrophils
• acts mainly via CC chemokine receptor CCR1
• also binds to CCR3
• CCL15(22-92), CCL15(25-92) & CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine CCL15

Structure

• monomer
• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• most abundant in heart, skeletal muscle & adrenal gland
• lower levels in placenta, liver, pancreas & bone marrow

Pathology

• CCL15(22-92), CCL15(25-92) & CCL15(29-92) are found in high levels in synovial fluid from patients with rheumatoid arthritis

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6359
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6359
• OMIM: https://mirror.omim.org/entry/601393
• UniProt: http://www.uniprot.org/uniprot/Q16663.html