T lymphocyte (T-cell, thymocyte)
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Introduction
Produced in the thymus from blood-borne progenitors from bone marrow & fetal liver. Immature thymocytes accumulate beneath the thymic capsule, then migrate inward through the cortex, corticomedullary junction to the medulla, undergoing proliferation & differentiation. Mature, self-tolerant MHC-restricted T cells are exported to the periphery to seed/replenish the peripheral T cell supply.
Pathology
Surface markers:
- T helper: CD3, CD4
- T cytotoxic: CD3, CD8
- naive/resting T cells: CD3, CD4 or CD8, CD45RA
- memory/activated T cells: CD3, CD4 or CD8, CD45RO
Pool size:
More general terms
More specific terms
- cytotoxic (suppressor) T cell (CD8+, CTL)
- EL 4 cell
- helper T cell (T4 lymphocyte, CD4+)
- Jurkat cell
- Lutzner cell (mycosis cell)
- mucosal-associated invariant T cell (MAIT cell)
- regulatory T cell
- Sezary cell
Additional terms
References
- ↑ Berzins et al. Trends in Molecular Medicine 8:469-76, 2002
- ↑ Murasko DM & Berstein ED, Immunology of Aging, In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 99
- ↑ Jump up to: 3.0 3.1 ARUP Consult: T-Cell Deficiency Disorders, Inherited deprecated reference