T lymphocyte (T-cell, thymocyte)

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Produced in the thymus from blood-borne progenitors from bone marrow & fetal liver. Immature thymocytes accumulate beneath the thymic capsule, then migrate inward through the cortex, corticomedullary junction to the medulla, undergoing proliferation & differentiation. Mature, self-tolerant MHC-restricted T cells are exported to the periphery to seed/replenish the peripheral T cell supply.


Surface markers:

Pool size:

see ARUP consult[3]

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  1. Berzins et al. Trends in Molecular Medicine 8:469-76, 2002
  2. Murasko DM & Berstein ED, Immunology of Aging, In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 99
  3. 3.0 3.1 ARUP Consult: T-Cell Deficiency Disorders, Inherited deprecated reference