regulatory T cell

Introduction

subsets of CD4+ cells Foxp3, GITR, LAG-3, CTLA4, CD25+, CD46+ CD4+ ,

Function

• suppress or regulate T-cells
• T-regulatory 1 cells suppress immune responses by secreting IL-10, & thereby prevent autoimmunity (putative)
• a number of viral & bacterial pathogens seem to exploit this property & directly induce an immunosuppressive phenotype in T-cells by binding to CD46

More general terms

• T lymphocyte (T-cell, thymocyte)