lymphocyte activation gene 3 protein; LAG-3; FDC protein; CD223 (LAG3, FDC)

Function

• role in lymphocyte activation
• binds to HLA class-II antigens

Structure

• contains 3 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

plasma membrane; single-pass type 1 membrane protein

Expression

expressed onn cell surface of activated NK cells & T-lymphocytes

More general terms

• CD antigen
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P18627.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3902
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3902
• OMIM: https://mirror.omim.org/entry/153337