tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; activation-inducible TNFR family receptor (TNFRSF18, AITR, GITR, UNQ319/PRO364)

Function

• receptor for TNFSF18
• seems to be involved in interactions between activated T-lymphocytes & endothelial cells & in the regulation of T-cell receptor-mediated cell death mediated NF-kappa-B activation via the TRAF2/NIK pathway
• binds to TRAF1, TRAF2, & TRAF3, but not TRAF5 & TRAF6
• binds through its C-terminus to SIVA1/SIVA

Structure

contains 3 TNFR-Cys repeats

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

• expressed in lymph node, peripheral blood leukocytes &
• up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8784
• OMIM: https://mirror.omim.org/entry/603905
• UniProt: http://www.uniprot.org/uniprot/Q9Y5U5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8784