mitogen-activated protein kinase kinase kinase 14 (MAP3K14, NF kappa-B inducing kinase, NIK, HsNIK, MAP3K14)

Function

• activated by lymphotoxin beta
• interacts with traf2, traf5, traf6, IKK-alpha (putative)
• role in activation of NF kappa-B
• induces processing of NF kappa-B 2/p100.
• activates MEK1 (putative)
• exclusively involved in the activation of NF-kappa-B & its transcriptional activity
• could act in a receptor-selective manner (putative)
• interacts with PELI3
• autophosphorylated

ATP + a protein <--> ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm

Expression

• weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary & colon

More general terms

• MAP3K/MEKK

Database

• OMIM: https://mirror.omim.org/entry/604655
• UniProt: http://www.uniprot.org/uniprot/Q99558.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9020
• Kegg: http://www.genome.jp/dbget-bin/www_bget?