mitogen-activated protein kinase kinase kinase (MAP3K) or MEK kinase (MEKK)
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Introduction
MEKK is activated by ras independently of raf. MEKK is actually more efficient in activating jun kinase kinase (JNKK) than MAP2K/MEK & functions to propagate the intracellular signal of ras to the jun kinases (JNK).
More general terms
More specific terms
- mitogen-activated protein kinase kinase kinase 1 (MAP3K1, MAPK/ERK kinase kinase 1, MEKK1, MAPKKK1, MEKK)
- mitogen-activated protein kinase kinase kinase 10 (MAP3K10, mixed lineage kinase [MLK] 2, MLK2, MST)
- mitogen-activated protein kinase kinase kinase 11 (mixed lineage kinase 3, src-homology 3 domain-containing proline-rich kinase, MAP3K11, MLK3, SPRK)
- mitogen-activated protein kinase kinase kinase 12 (MAP3K12, leucine zipper protein kinase, ZPK, dual leucine zipper bearing kinase, DLK, MAPK-upstream kinase, MUK)
- mitogen-activated protein kinase kinase kinase 13 (mixed lineage kinase, MLK, leucine zipper-bearing kinase, MAP3K13, LZK)
- mitogen-activated protein kinase kinase kinase 14 (MAP3K14, NF kappa-B inducing kinase, NIK, HsNIK, MAP3K14)
- mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
- mitogen-activated protein kinase kinase kinase 16 (MAP3K16, TAO1 kinase, serine/threonine protein kinase TAO1, thousand & one amino acid protein 1, STE20-like kinase PSK2, kinase from chicken homolog B, hKFC-B, TAOK1 KIAA1361)
- mitogen-activated protein kinase kinase kinase 2 (MAP3K2, MAPK/ERK kinase kinase 2, MEKK2, MAPKKK2)
- mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3, MEK kinase 3, MAP3K3, MAPK/ERK kinase kinase 3, MEKK3, MAPKKK3)
- mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase kinase 4, MEK kinase 4, MAP three kinase 1, MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1)
- mitogen-activated protein kinase kinase kinase 5 (MAP3K5, MAPK/ERK kinase kinase 5, MEKK5, apoptosis signal-regulating kinase 1, ASK-1, ASK1, MAPKKK5)
- mitogen-activated protein kinase kinase kinase 6 (MAP3K6, apoptosis signal-regulating kinase 2, ASK-2, ASK2, MAPKKK6, MEKK6)
- mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1 (MAP3K7, TAK1)
- mitogen-activated protein kinase kinase kinase 8 (MAP3K8, cot proto-oncogene protein, cot kinase, Cot/Tpl-2, cancer Osaka thyroid oncogene protein, ESTF)
- mitogen-activated protein kinase kinase kinase 9 (MAP3K9, mixed lineage kinase [MLK] 1, MLK1, PRKE1)
- mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4 (MLK4, KIAA1804)
References
- ↑ Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science. 1993 Apr 16;260(5106):315-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8385802
- ↑ Lange-Carter CA, Johnson GL. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science. 1994 Sep 2;265(5177):1458-61. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8073291
- ↑ Minden A et al Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science. 1994 Dec 9;266(5191):1719-23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7992057
- ↑ Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 1995 Apr 14;268(5208):286-90. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716521