mitogen-activated protein kinase kinase kinase 7; transforming growth factor-beta-activated kinase 1 (MAP3K7, TAK1)

Function

• mediates TGF-beta signal transduction
• component of a protein kinase signal transduction cascade
• mediator of TGF-beta signal transduction
• stimulates NF-kappa-B activation & the p38 MAPK pathway
• binds both upstream activators & downstream substrates in multimolecular complexes
• interacts with MAP3K7IP1 & MAP3K7IP2
• interacts with PPM1L
• association with MAP3K7IP1 promotes autophosphorylation & subsequent activation

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Polymorphism

• SNPs in intron 1 of MAP3K7 are associated in longevity

More general terms

• MAP3K/MEKK

Database

• UniProt: http://www.uniprot.org/uniprot/O43318.html
• OMIM: https://mirror.omim.org/entry/602614
• UniProt: http://www.uniprot.org/uniprot/O43318.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6885