protein phosphatase-2C epsilon; PP2C-epsilon; protein phosphatase 1L; protein phosphatase 1-like (PPM1L, PP2CE)

Function

• acts as suppressor of the SAPK signaling pathways by associating with & dephosphorylating MAP3K7/TAK1 & by attenuating the association between MAP3K7/TAK1 & MAP2K4 or MAP2K6 phosphoprotein + H2O <--> protein + phosphate

Cofactor: binds 2 Mg+2 or Mn+2 per subunit

Structure

• belongs to the PP2C family
• contains 1 PP2C-like domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• highly expressed in heart, placenta, lung, liver, kidney, pancreas

More general terms

• protein phosphatase-2C
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5SGD2.html