mitogen activated protein kinase kinase 6 (dual specificity mitogen-activated protein kinase kinase 6, MAPK/ERK kinase 6, MEK6, SAPKK3, MAP2K6, MKK6, PRKMK6)

Function

• MAP2K3 & MAP2K6 activate p38MAPKs
• catalyzes concomitant phosphorylation of a Thr & a Tyr in MAP kinase p38 exclusively
• interacts with Yersinia yopJ
• probably activated by dual phosphorylation on Ser-207 & Thr-211
• weakly autophosphorylated
• acetylation of Ser-207 & Thr-211 by Yersinia yopJ prevents phosphorylation & activation, thus blocking the MAPK signaling pathway

ATP + a protein = ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
• contains 1 protein kinase domain

Alternative splicing

named isoforms=2

Expression

• isoform 2 is only expressed in skeletal muscle
• isoform 1 is expressed in skeletal muscle, heart > liver, pancreas
• strongly activated by UV, anisomycin, & osmotic shock but not by phorbol esters, NGF or EGF

More general terms

• MAP2K/MEK

Database

• UniProt: http://www.uniprot.org/uniprot/P52564.html
• OMIM: https://mirror.omim.org/entry/601254
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5608