p38MAPK subfamily

Function

• roles in inflammation
• roles in stress responses
• roles in apoptosis
• differentiation
  • adipocytes
  • cardiomyocytes
  • erythroblasts
  • myoblasts
  • neurons
• proliferation
  • fibroblasts
  • hematopoietic cells
• cell survival
  • cardiomyocytes
  • fibroblasts
  • neurons
• SB203580 inhibits p38MAPK-alpha & p38MAPK-beta
• SB203580 does not inhibit p38MAPK-gamma or p38MAPK-delta

Pharmacology

• anti-inflammatory agent losmapimod inhibits p38MAPKs

Comparative biology

• p38MAPK family members affect development & oogenesis in drosophila

More general terms

• MAP kinase

More specific terms

• mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; stress-activated protein kinase 2 (MAPK11, PRKM11, SAPK2)
• mitogen-activated protein kinase 12; extracellular signal-regulated kinase 6; ERK-6; ERK5; stress-activated protein kinase 3; mitogen-activated protein kinase p38 gamma; MAP kinase p38 gamma (MAPK12, ERK6, SAPK3)
• mitogen-activated protein kinase 13; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MAP kinase p38 delta (MAPK13, PRKM13, SAPK4)
• mitogen-activated protein kinase 14; mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A (MAPK14,...