mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; stress-activated protein kinase 2 (MAPK11, PRKM11, SAPK2)

Function

• kinase involved in a signal transduction pathway activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress
• phosphorylates preferentially transcription factor ATF2
• activated by phosphorylation on Thr & Tyr by MKK6
• inhibited by pyridinyl-imidazole related compounds
• dually phosphorylated on Thr-180 & Tyr-182, which activates the enzyme (probable)

Cofactor: Mg+2 (putative)

Structure

• TXY motif contains the Thr & Tyr whose phosphorylation activates the MAP kinases
• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
• contains 1 protein kinase domain

Expression

• highest levels in the brain & heart
• also expressed in placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• p38MAPK subfamily

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5600
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5600
• OMIM: https://mirror.omim.org/entry/602898
• UniProt: http://www.uniprot.org/uniprot/Q15759.html