mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1 binding protein 2, TAB2, MAP3K7IP2, KIAA0733)

Function

• adapter linking MAP3K7 &TRAF6
• mediates MAP3K7 activation in IL1 signaling
• interacts with MAP3K7, TRAF6, NCOR1, HDAC3
• ubiquitinated following IL1 stimulation or TRAF6 overexpression

Compartment

peripheral membrane, cytoplasm (activated)

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• MAP3K7 interacting protein
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/605101
• UniProt: http://www.uniprot.org/uniprot/Q9NYJ8.html