nuclear receptor corepressor 1; N-CoR1; N-CoR (NCOR1 KIAA1047)

Function

• mediates transcriptional repression by certain nuclear receptors
• interacts with unliganded nuclear receptors, including: RXR, RAR, T3R, & PPAR-alpha to keep them in a repressed state
• part of a complex which promotes histone deacetylation & formation of repressive chromatin structures which may impede the access of basal transcription factors
• ubiquitinated; mediated by SIAH2 & leading to its subsequent proteasomal degradation (putative)
• interacts with SIAH2, HDAC7, SAP30, SIN3A & SIN3B
• forms a large corepressor complex that contains SIN3A/B & histone deacetylases HDAC1 & HDAC2; this complex associates with the thyroid hormone receptor (erbA) & the retinoid acid receptors (RAR) in the absence of ligand
• interacts with DACH1
• component of the N-cor repressor complex
• interacts with TRIM28 & MJD2A/JHDM3A
• interacts with ZBTB33/KAISO
  • interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides
• interacts with the catalytic domain of HDAC9
• interacts with CBFA2T3 & HEXIM1
• interacts with C1D

Structure

• the N-terminal region contains 3 independent domains capable of mediating transcriptional repression (RD1, RD2 & RD3)
• the C-terminal region contains 2 separate nuclear receptor-interacting domains (ID1 & ID2), each of which contains a conserved sequence referred to as the CORNR box
  • the CORNR box is necessary & sufficient for binding to unligated nuclear hormone receptors
  • sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (putative)
• belongs to the N-CoR nuclear receptor corepressors family
• contains 2 SANT domains

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• nuclear receptor corepressor (N-COR)
• phosphoprotein

Component of

• N-cor repressor complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9611
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9611
• OMIM: https://mirror.omim.org/entry/600849
• UniProt: http://www.uniprot.org/uniprot/O75376.html