paired amphipathic helix protein sin3b; histone deacetylase complex subunit sin3b; transcriptional corepressor sin3b (SIN3B, KIAA0700, msin3B)

Function

• transcriptional repressor
• interacts with MXI1 to repress MYC responsive genes; antagonizes MYC oncogenic activities
• interacts with MAD-MAX heterodimers by binding to MAD; heterodimer represseses transcription by tethering SIN3B to DNA
• forms a complex with FOXK1 which represses transcription
• interacts with FOXK1, MXI1, MAD, NCOR1, SAP30, SDS3, HDAC1, HCFC1

Structure

• PAH domain 2 of mSin3A/mSin3B required for MAD & MXI1 binding; first 25 aa of MAD also required

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23309
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23309
• OMIM: https://mirror.omim.org/entry/607777
• UniProt: http://www.uniprot.org/uniprot/O75182.html