forkhead box protein K1; myocyte nuclear factor; MNF (FOXK1)

Function

• transcriptional regulator
• binds to the upstream enhancer region (CCAC box) of myoglobin gene
• role in myogenic differentiation & in remodeling processes of adult muscles that occur in response to physiological stimuli
• interacts with SIN3B to form a complex which represses transcription
• phosphorylated

Structure

• contains 1 FHA domain
• contains 1 fork-head DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

expressed both developing & adult tissues

Pathology

• expressed in tumors of the brain, colon, lymph node

More general terms

• forkhead family transcription factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=221937
• UniProt: http://www.uniprot.org/uniprot/P85037.html