sin3-associated peptide, 30kD (SAP30, histone deacetylase complex subunit SAP30, sin3 corepressor complex subunit SAP30)

Function

• protein subunit of sin3 repressor complex
• functional recruitment of Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes
• transcription repression by N-CoR
• interacts with SIN3A, SIN3B, HDAC2, NCOR1, HDAC1, HCFC

Compartment

nucleus

Expression

• expressed in all tissues tested
• highest levels in pancreas, ovary, PBL, spleen, thymus
• lowest levels in brain, placenta, lung, kidney

More general terms

• protein subunit

Additional terms

• sin3-protein

Component of

• sin3 repressor complex

Database

• OMIM: https://mirror.omim.org/entry/603378
• UniProt: http://www.uniprot.org/uniprot/O75446.html