Sin3 histone deacetylase corepressor complex component SDS3 (suppressor of defective silencing 3 protein homolog, SUDS3, SDS3, SAP45)

Function

• regulatory protein, represses transcription & augments histone deacetylase activity of HDAC1
• role in tumor suppressor pathways (putative)
• component of SIN3 histone deacetylase corepressor complex
• interacts with SIN3A.
• interaction with SIN3B enhances interaction between SIN3B & HDAC1 to form a complex
• interacts with HCFC1

Structure

• homodimer

More general terms

• protein subunit

Component of

• sin3 repressor complex
• Sin3A corepressor complex

Database

• OMIM: https://mirror.omim.org/entry/608250
• UniProt: http://www.uniprot.org/uniprot/Q9H7L9.html