transcriptional regulator Kaiso (zinc finger & BTB domain-containing protein 33, ZBTB33, KAISO, ZNF348)

Function

• transcriptional regulator with bimodal DNA-binding specificity
• binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'
• binds to the non-methylated consensus sequence 5'-CTGCNA-3'
• recruits the N-CoR repressor complex to promote histone deacetylation & the formation of repressive chromatin structures in target gene promoters
• repression of target genes of the Wnt signaling pathway ?
• transcriptional activation of a subset of target genes by the recruitment of CTNND2
• self-associates
• interacts with CTNND2
• interaction with CTNND1 inhibits binding to both methylated & non-methylated DNA
• interacts with NCOR1
• interaction with KPNA2/RCH1 may mediate nuclear import
• induced in vascular endothelium by wounding
  • effect is potentiated by prior laminar shear stress, which enhances wound closure

Structure

• contains 1 BTB domain (POZ domain)
• contains 3 C2H2-type zinc fingers

Compartment

nucleus, cytoplasm

Expression

expressed in vascular endothelium

More general terms

• zinc finger protein
• transcription factor (TF)
• DNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/300329
• UniProt: http://www.uniprot.org/uniprot/Q86T24.html