catenin delta-2; delta-catenin; neural plakophilin-related ARM-repeat protein; NPRAP; neurojungin; GT24 (CTNND2, NPRAP)

Function

• transcriptional activator when bound to ZBTB33 (putative)
• may be involved in neuronal cell adhesion & tissue morphogenesis & integrity by regulating adhesion molecules
• binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain
• interacts with PDZD2
• interacts with ZBTB33 (putative)
• binds to PSEN1
• interacts with RGNEF
• interacts (via C-terminus) with FRMPD2 (via 2nd PDZ domain)
• phosphorylated upon DNA damage, probably by ATM or ATR
• phosphorylated by CDK5

Structure

• O-glycosylated (putative)
• belongs to the beta-catenin family
• contains 9 ARM repeats

Compartment

• nucleus (putative)
• cell junction, adherens junction (putative)

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Expression

predominantly expressed in brain

More general terms

• catenin
• beta catenin family protein
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1501
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1501
• OMIM: https://mirror.omim.org/entry/604275
• UniProt: http://www.uniprot.org/uniprot/Q9UQB3.html