PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain

Introduction

Domain found in MAGK superfamily proteins/scaffold proteins of the postsynaptic density. They are modular domains of about 90 amino acid residues, specialized to binding of ES[D/E]V motifs found on the C-terminus of glutamate receptor epsilon subunits of the NMDA receptor.

The PDZ domains of SAP-90 also interact with SynGAP1.

More general terms

• domain
• binding site

Additional terms

• PDZ domain-containing protein