catenin delta-1; p120 catenin; p120(ctn); cadherin-associated Src substrate; CAS; p120(cas) (CTNND1, KIAA0384)

Function

• binds to & inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (putative)
• may associate with & regulate cell adhesion properties of both C-cadherin & E-cadherin
• implicated both in cell transformation by SRC & in ligand- induced receptor signaling through the EGFR, PDGFR, CSF1R & ERBB2
• promotes GLIS2 C-terminal cleavage
• belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, & gamma- catenin
• binds to the C-terminal fragment of PSEN1 & mutually competes for E-cadherin
• interacts with ZBTB33
• interacts with GLIS2
• phosphorylated (putative)

Structure

• a possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted
• belongs to the beta-catenin family
• contains 10 ARM repeats

Compartment

• cytoplasm. nucleus. cell membrane
• interaction with GLIS2 promotes nuclear translocation (putative)

Alternative splicing

named isoforms=32

Expression

• expressed in vascular endothelium
• induced in vascular endothelium by wounding; this effect is potentiated by prior laminar shear stress, which enhances wound closure

Pathology

• may contribute to cell malignancy
• complete loss of expression was observed in ~ 10% of invasive ductal breast carcinomas

More general terms

• catenin
• beta catenin family protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1500
• OMIM: https://mirror.omim.org/entry/601045
• UniProt: http://www.uniprot.org/uniprot/O60716.html