zinc finger protein GLIS2 (GLI-similar 2, neuronal Krueppel-like protein, GLIS2, NKL)

Function

• role as transcription repressor or as transcription activator, depending on cell context
• represses transcriptional activation mediated by CTNNB1 in Wnt pathway
• recruits corepressors CTBP1 & HDAC3
• role in neuron differentiation
• interacts with CTBP1 & HDAC3
• interacts with CTNNB1, CTNND1
• C-terminus cleavage is induced by interaction with CTNND1 & enhanced by Src tyrosine kinase

Structure

• belongs to the GLI C2H2-type zinc-finger protein family.
• contains 5 C2H2-type zinc fingers
• C2H2-type zinc finger 1 has a major repressor function & is required for CTNNB1 binding

Compartment

nuclear speckle, cytoplasm

Expression

• expressed in kidney > heart, lung, placenta
• expressed in colon

More general terms

• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• OMIM: https://mirror.omim.org/entry/608539
• UniProt: http://www.uniprot.org/uniprot/Q9BZE0.html