DNA-binding protein inhibitor ID-2; inhibitor of DNA binding 2 (ID2)

Function

• ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding
• ID2 may be an inhibitor of tissue-specific gene expression
• heterodimer with other HLH proteins

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Expression

• highly expressed in early fetal tissues, including those of the central nervous system
• found in most early fetal tissues but not in the corresponding mature tissues

More general terms

• DNA-binding protein inhibitor; inhibitor of DNA binding (ID)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3398
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3398
• OMIM: https://mirror.omim.org/entry/600386
• UniProt: http://www.uniprot.org/uniprot/Q02363.html