tumor necrosis factor (TNF) receptor-associated factor 6; interleukin 1 signal transducer; RING finger protein 85 (TRAF6, RNF85)

Function

• adapter protein & signal transducer
• links members of the TNF receptor family to different signaling pathways
• IL-1 signaling pathway via MYD88 & IRAK kinases
• IL-17 signaling (putative)
• activation of NF-kappa-B & JNK (putative)
• E3 ubiquitin ligase (putative)
• binds to TNFRSF5, TNFRSF11A, NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRIP, TRAF, TTRAP, UBE2V1
• interacts with IL17R, SQSTM1, PELI1, PELI2, PELI3, MAVS, TAX1BP1

* see figure

Compartment

cytoplasm

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• TRAF
• ring finger protein

Database

• OMIM: https://mirror.omim.org/entry/602355
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7189
• UniProt: http://www.uniprot.org/uniprot/Q9Y4K3.html