interleukin-1 receptor associated kinase 4 (IRAK4, NY-REN-64 antigen)
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Function
- recruitment of IRAK1 to the IL-1 receptor complex
- phosphorylates IRAK1
- interacts with IL1RL1
Structure
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
- contains 1 death domain
- contains 1 protein kinase domain
Pathology
- defects in IRAK4 are the cause of
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9NWZ3.html
- ↑ IRAK4base; Note: IRAK4 mutation db http://bioinf.uta.fi/IRAK4base/
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/irak4/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51135
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51135
- OMIM: https://mirror.omim.org/entry/606883
- OMIM: https://mirror.omim.org/entry/607676
- OMIM: https://mirror.omim.org/entry/610799
- UniProt: http://www.uniprot.org/uniprot/Q9NWZ3.html