recurrent invasive pneumococcal disease

Introduction

defined as 2 episodes of infection due to pneumococcus occurring at least 1 month apart, whether caused by the same or different serotypes or strains of Streptococcus pneumoniae

Epidemiology

• occurs in at least 2% of patients in most series
• most important known risk factor for subsequent invasive pneumococcal disease

Genetics

• associated with defects in IRAK4 (type 1)
• associated with defects in IKBKG (type 2)

More general terms

• recurrent bacterial infection
• genetic disease of the immune system
• immunodeficiency; immunodeficiency syndrome

Database

• OMIM: https://mirror.omim.org/entry/610799
• OMIM: https://mirror.omim.org/entry/300640