Streptococcus pneumoniae (pneumococcus)

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Introduction

Commonly carried in the oropharyngeal area.

Epidemiology

serotype 2020 2021
10A 16 5
11A 26 16
12F 6 7
13 1 3
14 3 0
15A 26 32
15B 11 10
15C 9 3
16F 22 23
17F 3 2
18C 0 2
19A 18 11
19F 15 14
20 15 11
21 1 1
22F 58 40
23A 23 38
23B 12 11
23F 1 0
24F 1 0
28A 1 3
3 106 63
31 12 12
33F 12 14
34 9 7
35B 29 43
35F 10 21
37 1 0
38 3 0
4 7 8
6B 0 2
6C 12 8
7C 14 13
7F 4 1
8 18 8
9N 32 35
9V 1 0
mixed 122 142
NT 3 0

, mixed = mixed serotypes

Pathology

Genetics

Laboratory

Complications

  • 1 month mortality men with mean age 63 years is 12%
  • 10-year survival of patients with pneumococcal pneumonia, men with mean age 63 years is < 70%[8] (normal > 95%)[8]

Differential diagnosis

Management

More general terms

More specific terms

Additional terms

References

  1. Manual of Medical Therapeutics, 28th edition, Ewald & McKenzie (eds) Little, Brown & Co, 1995, pg 301
  2. 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16. American College of Physicians, Philadelphia 1998, 2009, 2012
  3. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 796
  4. 4.0 4.1 4.2 Journal Watch 22(4):29, 2002 Nasrin et al, BMJ 324:28, 2002
  5. 5.0 5.1 Journal Watch 24(17):138, 2004 Madhi SA, Klugman KP, The Vaccine Trialist Group. A role for Streptococcus pneumoniae in virus-associated pneumonia. Nat Med. 2004 Aug;10(8):811-3. Epub 2004 Jul 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15247911
  6. 6.0 6.1 Journal Watch 24(18):147, 2004 Baddour LM, Yu VL, Klugman KP, Feldman C, Ortqvist A, Rello J, Morris AJ, Luna CM, Snydman DR, Ko WC, Chedid MB, Hui DS, Andremont A, Chiou CC; International Pneumococcal Study Group. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med. 2004 Aug 15;170(4):440-4. Epub 2004 Jun 07. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15184200
  7. 7.0 7.1 ARUP Consult: Streptococcus pneumoniae The Physician's Guide to Laboratory Test Selection & Interpretation https://arupconsult.com/content/streptococcus-pneumoniae
  8. 8.0 8.1 8.2 Sandvall B et al. Long-term survival following pneumococcal pneumonia. Clin Infect Dis 2013 Apr 15; 56:1145. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23300240
  9. Wong A, Marrie TJ, Garg S et al Increased risk of invasive pneumococcal disease in haematological and solid-organ malignancies. Epidemiol Infect. 2010 Dec;138(12):1804-10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20429967
  10. 10.0 10.1 Centers for Disease Control & Prevention Public Health Surveillance. September 29, 2023 2016-2021 Serotype Data for Invasive Pneumococcal Disease Cases by Age Group from Active Bacterial Core surveillance https://data.cdc.gov/Public-Health-Surveillance/2016-2021-Serotype-Data-for-Invasive-Pneumococcal-/qvzb-qs6p