oxacillin
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Introduction
Indications
- bacterial infections due to susceptible organisms
- empiric treatment for fever of unknown origin[3]
Dosage
- 1-2 g IV/IM every 4-6 hours.
- Pediatrics: 50-100 mg/kg/day.
- 500-1000 mg PO every 4-6 hours.
- Pediatrics: 5- mg/kg/day divided every 4-6 hours
Tabs: 250 & 500 mg.
Suspension: 250 mg/5 mL.
Antimicrobial activity
- Staphylococcus aureus
- not methicillin-resistant S aureus {MRSA})
- less active than other penicillins against Streptococcus sp.
- lacks enterococcus & anaerobic coverage
Adverse effects
Mechanism of action
- inhibition of bacterial wall synthesis
- active against penicillinase-producing organisms
More general terms
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 161.
- ↑ Jump up to: 3.0 3.1 3.2 Deprecated Reference
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64714
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4608
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6196
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=23663
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4607
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441399