oxacillin

Introduction

2nd generation penicillin.

Indications

• bacterial infections due to susceptible organisms
  • skin or soft tissue infections
  • osteomyelitis
• empiric treatment for fever of unknown origin

Dosage

• 1-2 g IV/IM every 4-6 hours.
• Pediatrics: 50-100 mg/kg/day.
• 500-1000 mg PO every 4-6 hours.
• Pediatrics: 5- mg/kg/day divided every 4-6 hours

Tabs: 250 & 500 mg.

Suspension: 250 mg/5 mL.

Antimicrobial activity

• Staphylococcus aureus
  • not methicillin-resistant S aureus {MRSA})
• less active than other penicillins against Streptococcus sp.
• lacks enterococcus & anaerobic coverage

Adverse effects

• hypersensitivity
  • skin rash
  • fever
• hepatitis

Mechanism of action

• inhibition of bacterial wall synthesis
• active against penicillinase-producing organisms

More general terms

• 2nd generation penicillin (penicillinase-resistant)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64714
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4608
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6196
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=23663
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4607
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441399