hepatitis
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Etiology
- viral hepatitis
- viral infections producing systemic disease[3]
- yellow fever, EBV, CMV, HIV, rubella, rubeolla, coxsackie B, adenovirus, Herpes simplex, Herpes zoster
- other infections[3]
- alcoholic hepatitis
- non-alcoholic steatohepatitis (NASH)
- drug-induced hepatitis
- autoimmune chronic hepatitis
- most often affects young women
- associated symptoms: arthralgias, arthritis, skin rash, fever
- fatty liver of pregnancy
- ischemic hepatitis
- also see chronic hepatitis
Epidemiology
- 5 cases of adenovirus type 41 infection identified in Alabama in Nov 2021[5]
Clinical manifestations
- malaise
- nausea/vomiting
- anorexia
- fatigue
- diarrhea
- low-grade fever
- hepatomegaly with tenderness
- jaundice
- dark urine
Laboratory
- liver function tests
- increased serum transaminases
- increased serum gamma-glutamyltransferase (serum GGT)
- increased serum alkaline phosphatase
- serum bilirubin: hyperbilirubinemia
- increased lactate dehydrogenase (LDH)
- markers of viral hepatitis, hepatitis serology
- markers of autoimmune hepatitis
- increased erythrocyte sedimentation rate (ESR)
- positive antinuclear antibody
- positive LE cell
- antinuclear nuclear antibody (autoimmune)
- antimitochondrial antibody
- eosinophilia in drug-induced hepatitis
- see ARUP consult[4]
Radiology
Differential diagnosis
Management
- management of viral hepatitis
- autoimmune chronic hepatitis
- indications for hospitalization
- dehydration with inability to tolerate oral fluids
- signs of hepatic failure
- prolongation of prothrombin time
- hepatic encephalopathy
More general terms
More specific terms
- acute hepatitis
- alcoholic hepatitis
- autoimmune hepatitis
- cholestatic hepatitis
- chronic hepatitis
- drug/toxin-induced hepatitis
- non-alcoholic steatohepatitis (NASH)
- portal triaditis
- viral hepatitis
Additional terms
References
- ↑ Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 369-70
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ 3.0 3.1 3.2 Ferri's Clinical Advisor, Instant Diagnosis and Treatment, Ferri FF (ed), Mosby, Philadelphia, 2003
- ↑ 4.0 4.1 ARUP Consult: Hepatitis, Acute deprecated reference
Hepatitis Virus Screening Algorithm https://arupconsult.com/algorithm/hepatitis-virus-screening-algorithm - ↑ 5.0 5.1 Centers for Disease Control & Prevention (CDC) Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology. CDC Health Alert Network. April 21, 2022 https://emergency.cdc.gov/han/2022/han00462.asp
- ↑ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) What Is Viral Hepatitis? https://www.niddk.nih.gov/health-information/liver-disease/viral-hepatitis/what-is-viral-hepatitis