cholestatic hepatitis

Etiology

• viral hepatitis
  • hepatitis A
  • hepatitis B
  • hepatitis C
• pharmaceutical agents
• alcoholic hepatitis
• congestive heart failure
• chronic pancreatitis
• Hodgkin's disease
• fatty liver

Clinical manifestations

• jaundice
• pruritus
• hepatomegaly
• fatigue
• indigestion

Laboratory

• serum direct bilirubin is elevated
• serum bile acids elevated 10-20 fold
• serum alkaline phosphatase is elevated
• serum gamma-glutamyltransferase is elevated
• serum 5'nucleotidase is elevated
• serum ALT is moderately elevated
• serum cholesterol is elevated

Diagnostic procedures

• abdominal ultrasound

Management

• treat underlying etiology
• nutrition
  • low fat, low cholesterol diet
  • vitamin supplementation (especially fat-souble vitamins)
• cholestyramine may help reduce itch (see cholestatis)

More general terms

• hepatitis
• cholestasis