vitamin supplementation

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[1][2][3][4][5][6][7][8][9][10][11]

Introduction

No evidence that vitamin supplementation prolongs life.[1]

Supplementation for most vitamins & minerals associated with lower all-cause mortality, but after adjustment for education & lifestyle factors, associations for all but lycopene disappeared[11]

Antioxidant vitamins do NOT prolong life[2]

No evidence to support the use of vitamin supplements or antioxidant supplements to prevent cardiovascular disease[7,10] or cancer[10]

US Preventive Services Task Force (2003) concluded:

Multivitamin supplementation reduced infection in:

  • healthy subjects < 65 years of age (RR* 0.6)[4]
  • diabetics (RR* 0.2)[4]
  • reduced number of days of infection (17 days yearly)[5]
  • non-significant decrease in incidence of infection[5]
  • no effect on odds of having at least one infection yearly[5]

* relative risk

More general terms

Additional terms

References

  1. ↑ 1.0 1.1 http://www.ahrq.gov/clinic/uspstfix.htm#review
  2. ↑ 2.0 2.1 Vivekananthan DP et al, Lancet 361:2017, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12814711
  3. ↑ Journal Watch 24(1):7, 2004 Morris CD & Carson S, Ann Intern Med 139:56, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12834320
  4. ↑ 4.0 4.1 4.2 Journal Watch 23(8):66, 2003 Barringer TA et al, Ann Intern Med 138:365, 2003 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/12614088 <Internet> http://www.annals.org/issues/v138n5/full/200303040-00005.html Fauzi W & Stampfer MJ, Ann Intern Med 138:430, 2003
  5. ↑ 5.0 5.1 5.2 5.3 Journal Watch 25(11):87, 2005 El-Kadiki A, Sutton AJ. Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta- analysis of randomised controlled trials. BMJ. 2005 Apr 16;330(7496):871. Epub 2005 Mar 31. Review. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15805125 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7496/871
  6. ↑ Prescriber's Letter 13(7): 2006 Multivitamins/Mineral and Chronic Disease Prevention Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220712&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. ↑ Myung S-K et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: Systematic review and meta-analysis of randomised controlled trials. BMJ 2013 Jan 18; 346:f10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23335472
  8. ↑ 8.0 8.1 Draft Recommendation Statement Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: U.S. Preventive Services Task Force Recommendation Statement DRAFT. Summary of Recommendations and Evidence http://www.uspreventiveservicestaskforce.org/draftrec2.htm
    Fortmann SP et al Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force. Ann Intern Med. Published online 12 November 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24217421 <Internet> http://annals.org/article.aspx?articleid=1767855
    Moyer VA et al Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med 2014 Apr 15; 160:558 http://annals.org/article.aspx?articleid=1832969
  9. ↑ Lamas GA et al High-Dose Multivitamins and Minerals After a Heart Attack. A Randomized Trial. Ann Intern Med. 2013;159(12):I-20-20. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24490264 <Internet> http://annals.org/article.aspx?articleid=1789246
    Grodstein F et al Does Long-Term Multivitamin Supplementation Help Cognitive Function in Men? Ann Intern Med. 2013;159(12):I-24-24. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24490265 <Internet> http://annals.org/article.aspx?articleid=1789247
    Guallar E et al Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements. Ann Intern Med. 2013;159(12):850-851-851 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24490268 <Internet> http://annals.org/article.aspx?articleid=1789253
  10. ↑ 10.0 10.1 Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018
  11. ↑ 11.0 11.1 Chen F, Du M, Blumberg JB et al Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults: A Cohort Study. Ann Intern Med. 2019. April 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30959527 https://annals.org/aim/article-abstract/2730525/association-among-dietary-supplement-use-nutrient-intake-mortality-among-u
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