leukocytosis
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Introduction
An increase in white blood cells (leukocytes) in peripheral blood. Generally, an increase in neutrophils (neutrophilia), but may be an increase in lymphocytes (lymphocytosis) especially in lymphoproliferative disorders.
Classification
Etiology
- increased production
- idiopathic
- drug-induced -> corticosteroids
- infection
- inflammation
- myeloproliferative disorders
- increased mobilization from the bone marrow
- corticosteroids
- WBC count peaks at 48 hours after receiving corticosteroids[2]
- mean increase in WBC by dose in prednisone equivalents (in hospital):
- 50 mg: 300/uL, 150 mg: 1700/uL, 380 mg: 4800/uL
- mean WBC decreases in hospitalized patients without corticosteroids[2]
- acute infection (endotoxin)
- inflammation (thermal injury)
- corticosteroids
- defective margination
- pharmaceutical agents
- stress
- excitement
- vigorous exercise
- leukocyte adhesion protein (C3bi {CR3} receptor) deficiency
- miscellaneous
- metabolic disorders
- drugs -> lithium
- metastatic carcinoma
- acute hemorrhage
- hemolysis
- also see lymphocytosis
More general terms
More specific terms
- basophilia
- CSF leukocytosis
- eosinophilia
- granulocytosis
- leukemoid reaction
- lymphocytosis
- neutrophilia
References
- ↑ Smith CJ, Kluck LA, Ruan GJ, et al. Leukocytosis and tobacco use: an observational study of asymptomatic leukocytosis. Am J Med. 2021;134:e31-e35. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32682870
- ↑ 2.0 2.1 2.2 Sullivan E et al. Elevation in white blood cell count after corticosteroid use in noninfected hospitalized patients. J Hosp Med 2025 Feb 11; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39932209 https://shmpublications.onlinelibrary.wiley.com/doi/10.1002/jhm.70008