CD11b; integrin alpha-M; cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; leukocyte adhesion receptor MO1; neutrophil adherence receptor; CD11 antigen-like family member B; (ITGAM, CD11B, CR3A)
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Function
- subunit of CD11b-CD18 complex (integrin CD11b/CD18)
Structure
- the integrin I-domain (insert) is a VWFA domain
- integrins with I-domains do not undergo protease cleavage
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
- contains 1 VWFA domain
Compartment
membrane
Expression
- granulocytes
- macrophages, monocytes
- predominantly expressed in monocytes & granulocytes
- activated microglia
- NK cells
- follicular dendritic cells
- myeloid cells at promyelocyte stage or later
Pathology
- expressed in:
- genetic variations in CD11b influence susceptibility to systemic lupus erythematosus[7]
More general terms
Additional terms
Component of
References
- ↑ Hibbs et al Science 251:1611 1991
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- ↑ Altieri et al J Immunol 1990 Jul 15;145(2):662-70
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3684
- ↑ 7.0 7.1 Hom G, Graham RR, Modrek B et al Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008 Feb 28;358(9):900-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18204098