AML-M5; acute monocytic leukemia
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Introduction
Pathology
- bone marrow biopsy
- bone marrow specimen stained with hematoxylin & eosin (image[3])
- leukemic infiltration of the marrow with monoblasts (Panel A, ;
Genetics
- juxtaposition of the interferon & c-ETS-1 proto-oncogene may be involved in the pathogenesis of monocytic leukemia
Clinical manifestations
- fever, fatigue, dyspnea (from case report[3])
- distended abdomen, hepatosplenomegaly
- cervical lymphadenopathy
Laboratory
- complete blood count:
- WBC may be > 100,000/uL, monocytes may be > 90%
- thrombocytopenia: platelet count may be < 40,000/uL
Complications
- tumor lysis syndrome & disseminated intravascular coagulation with chemotherapy induction[3]
- bone marrow necrosis (image[3])
- recurrence after treatment
Management
More general terms
More specific terms
References
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 726
- ↑ Mihova D Leukemia acute AML not otherwise categorized Acute monoblastic and acute monocytic leukemia (AML- M5) Pathology Outlines http://www.pathologyoutlines.com/topic/leukemiaacutemonocyticleukemia.html
- ↑ 3.0 3.1 3.2 3.3 3.4 Terao T, Matsuev K. Images in Clinical Medicine. Bone Marrow Necrosis in Acute Monoblastic Leukemia. N Engl J Med 2021; 384:650 Feb 18 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33596359 https://www.nejm.org/doi/full/10.1056/NEJMicm2026508