integrin alpha-M/beta-2 (CD11b/CD18, MAC1)

Function

• implicated in
  • adhesive interactions of monocytes, macrophages & granulocytes
  • uptake of complement-coated particles
• receptor for the iC3b fragment of component-C3
  • probably recognizes the R-G-D peptide in C3b
• receptor for fibrinogen
  • recognizes P1 & P2 peptides of fibrinogen gamma chain
• receptor for factor X
• receptor for ICAM1

Structure

• subunits: integrin alpha-M, integrin beta-2

Compartment

membrane

More general terms

• integrin
• complement-3b [C3b] receptor