coagulation factor X; Stuart factor; Stuart-Prower factor; contains: factor X light chain; factor X heavy chain; activated factor Xa heavy chain (F10)

Function

• precursor for coagulation factor Xa, a vitamin K- dependent serine protease that activates prothrombin to thrombin
• vitamin K-dependent, enzymatic carboxylation of some Glu allows the modified protein to bind Ca+2
• the activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway)
• the iron & 2-oxoglutarate dependent 3-hydroxylation of Asp & Asn is (R) stereospecific within EGF domains
• the two chains are formed from a single-chain precursor by the excision of two Arg & are held together by 1 or more disulfide bonds

Structure

• N- & O-glycosylated
• belongs to the peptidase S1 family
• contains 2 EGF-like domains
• contains 1 Gla (gamma-carboxy-glutamate) domain
• contains 1 peptidase S1 domain

Compartment

secreted

Expression

plasma; synthesized in the liver

Pathology

• defects in factor X are associated with factor X deficiency

More general terms

• coagulation factor
• enzyme precursor (zymogen)

More specific terms

• factor X variant

Additional terms

• coagulation cascade
• coagulation factor Xa

Component of

• factor ix/factor vii/factor x/protein c/protein s/prothrombin
• prothrombin complex concentrate (Autoplex-T, Kcentra)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2159
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2159
• OMIM: https://mirror.omim.org/entry/227600
• UniProt: http://www.uniprot.org/uniprot/P00742.html